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Cephalexin may be given on an empty stomach or with food to prevent stomach upset. Additional antibiotics should be avoided entirely while you are taking Cephalexin. Serious interactions of Cephalexin with other drugs are uncommon. Serious interactions of Cephalexin with other drugs are uncommon. Take Keflex at even intervals around the clock as prescribed by your doctor. Cephalexin is indicated in the treatment of the following infections caused by bacteria such as pneumonia and bone, ear, skin, and urinary tract infections. Keflex is a cephalosporin antibiotic and is used to treat a wide variety of bacterial infections.