Nexium is usually taken once a day at least one hour before a meal. Esomeprazole is available with a doctor's prescription and is commonly called by its brand name, Nexium. Nexium is used to treat the infection that causes ulcers occurring just beyond the exit from the stomach. What should my health care professional know before I take Esomeprazole? Nexium is usually taken once a day at least one hour before a meal.